Endocrine Abstracts

Testosterone supplementation increases whole body and appendicular skeletal muscle mass, maximal voluntary muscle strength, and leg power. However, concerns about the long term risks of prostate and cardiovascular disorders in older men treated with testosterone have encouraged efforts to develop selective androgen receptor modulators (SARM) that increase skeletal muscle mass and improve physical function without the adverse effects on prostate and cardiovascular outcomes. The...

Background: Millions of men worldwide take anabolic-androgenic steroids (AAS) to boost muscle growth, but risk psychosis, cardiomyopathy, stroke and death. Users avoid stopping AAS because they are fearful of low testosterone symptoms including sexual dysfunction, depression and suicidality. To avoid these symptoms, men often illicitly self-medicate a 2–12-week course of drugs including selective oestrogen receptor modulators to boost testicular function ...